Article
Human suppressor T cell clones lack CD28.
European journal of immunology - 1 Jun 1990
Li S G, Ottenhoff T H, Van den Elsen P, Koning F, Zhang L, Mak T, De Vries R R
Abstract excerpt
Previously we showed that certain T cell lines and clones from a lepromatous leprosy patient displayed a dose-dependent suppression of the proliferation of autologous T cells to Mycobacterium leprae (M. leprae) but not mitogen or an unrelated antigen. The latter cells were also cloned and did not display this suppressive activity, were CD4+ and proliferated vigorously to M. leprae presented by autologous HLA-DR...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD28 Antigens
- CD3 Complex
- Clone Cells
- Flow Cytometry
- Humans
- Leprosy, Borderline
- Lymphocyte Activation
- Mycobacterium leprae
- Phenotype