Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the Gene for Multidrug-Resistance–Associated Protein and Outcome in Patients with Neuroblastoma

25 Jan 1996

Abstract excerpt

BACKGROUND: Overexpression of the gene for the multidrug-resistance-associated protein (MRP) has been linked with resistance to chemotherapeutic agents (multidrug resistance) in vitro. The expression of MRP by neuroblastoma cells correlates with N-myc oncogene amplification, a well-established prognostic indicator in patients with neuroblastoma. METHODS: To relate MRP gene expression to established prognostic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Research and Treatments
Share to Drug Transport and Resistance Mechanisms
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8532000
DOI: 10.1056/nejm199601253340405

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the Gene for Multidrug-Resistance–Associated Protein and Outcome in Patients with NeuroblastomaPMID 8532000Read ↗

Association of High-Level <i>MRP1</i> Expression With Poor Clinical Outcome in a Large Prospective Study of Primary NeuroblastomaSemantic proximity Read ↗

Expression of multidrug transporterMRP4/ABCC4is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecanin vitroSemantic proximity Read ↗

Role of chemotherapy resistance genes in outcome of neuroblastomaSemantic proximity Read ↗

Role of the MRP1/ABCC1 Multidrug Transporter Protein in CancerSemantic proximity Read ↗

Expression of N-myc andMRP genes and their relationship to N-myc gene dosage and tumor formation in a murine neuroblastoma modelSemantic proximity Read ↗

ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastomaSemantic proximity Read ↗

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cellsSemantic proximity Read ↗

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for NeuroblastomaSemantic proximity Read ↗

MYCN-mediated regulation of the MRP1 promoter in human neuroblastomaSemantic proximity Read ↗

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.Semantic proximity Read ↗

Expression of the multidrug resistance, MDR1, gene in neuroblastomas.Semantic proximity Read ↗

Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.