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Article

ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma

1 Jan 2012

Abstract excerpt

Resistance to cytotoxic drugs is thought to be a major cause of treatment failure in childhood neuroblastoma, and members of the ATP-binding cassette (ABC) transporter superfamily may contribute to this phenomenon by active efflux of chemotherapeutic agents from cancer cells. As a member of the C subfamily of ABC transporters, multidrug resistance-associated protein MRP4/ABCC4 has the ability to export a variety...

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PMID: 23267433
DOI: 10.3389/fonc.2012.00178

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