Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

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Article

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

Cancer research - 15 Jan 1994

Grant C E, Valdimarsson G, Hipfner D R, Almquist K C, Cole S P, Deeley R G

Abstract excerpt

Amplification of the gene encoding multidrug resistance-associated protein (MRP) and overexpression of its cognate mRNA have been detected in multidrug-resistant cell lines derived from several different tumor types. To establish whether or not the increase in MRP is responsible for drug resistan...

Topics

Carcinoma, Small Cell
Doxorubicin
Drug Resistance
Gene Amplification
HeLa Cells
Humans
Lung Neoplasms
Neoplasm Proteins
Phenotype
RNA, Messenger
RNA, Neoplasm
Transfection
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8275468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8275468-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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