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Article

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

Cancer research - 15 Jan 1994

Grant C E, Valdimarsson G, Hipfner D R, Almquist K C, Cole S P, Deeley R G

Abstract excerpt

Amplification of the gene encoding multidrug resistance-associated protein (MRP) and overexpression of its cognate mRNA have been detected in multidrug-resistant cell lines derived from several different tumor types. To establish whether or not the increase in MRP is responsible for drug resistance in these cell lines, we have transfected HeLa cells with MRP expression vectors. The transfectants display an...

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PMID: 8275468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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