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Article

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cells

1 Nov 2001

Abstract excerpt

We have previously reported a strong correlation between poor prognosis in childhood neuroblastoma (NB) patients and high-level expression of the transmembrane efflux pump, Multidrug Resistance-associated Protein (MRP1), in NB tumour tissue. In this study, we inhibited the endogenous expression of MRP1 in 2 different NB tumour cell lines by stably transfecting an MRP1 antisense expression vector (MRP-AS)....

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Identifiers

PMID: 11720446
DOI: 10.1054/bjoc.2001.2144

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