Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells.

doi:10.1074/jbc.M109.078584

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Article

Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells.

The Journal of biological chemistry - 18 Jun 2010

Porro Antonio, Haber Michelle, Diolaiti Daniel, Iraci Nunzio, Henderson Michelle, Gherardi Samuele, Valli Emanuele, Munoz Marcia A, Xue Chengyuan, Flemming Claudia, Schwab Manfred, Wong Jason H, Marshall Glenn M, Della Valle Giuliano, Norris Murray D, Perini Giovanni

Abstract excerpt

Increased expression of specific ATP-binding cassette (ABC) transporters is known to mediate the efflux of chemotherapeutic agents from cancer cells. Therefore, establishing how ABC transporter genes are controlled at their transcription level may help provide insight into the role of these multifaceted transporters in the malignant phenotype. We have investigated ABC transporter gene expression in a large...

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Identifiers

PMID: 20233711
DOI: 10.1074/jbc.M109.078584
PMCID: PMC2885232

Genes

MYCN
MYC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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