Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of multidrug transporterMRP4/ABCC4is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecanin vitro

1 Apr 2005

Abstract excerpt

Members of the multidrug resistance-associated protein (MRP) family of transporters are believed to contribute to cytotoxic drug resistance and chemotherapy failure. We observed frequent MRP4 overexpression in aggressive primary neuroblastoma, a disease for which we have previously shown MRP1 to be a prognostic indicator. High MRP4 expression correlated with MYCN oncogene amplification and was significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Drug Transport and Resistance Mechanisms
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15827327
DOI: 10.1158/1535-7163.mct-04-0161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of multidrug transporterMRP4/ABCC4is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecanin vitroPMID 15827327Read ↗

Association of High-Level <i>MRP1</i> Expression With Poor Clinical Outcome in a Large Prospective Study of Primary NeuroblastomaSemantic proximity Read ↗

ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastomaSemantic proximity Read ↗

Expression of the Gene for Multidrug-Resistance–Associated Protein and Outcome in Patients with NeuroblastomaSemantic proximity Read ↗

Role of the MRP1/ABCC1 Multidrug Transporter Protein in CancerSemantic proximity Read ↗

Small-Molecule Multidrug Resistance–Associated Protein 1 Inhibitor Reversan Increases the Therapeutic Index of Chemotherapy in Mouse Models of NeuroblastomaSemantic proximity Read ↗

Role of chemotherapy resistance genes in outcome of neuroblastomaSemantic proximity Read ↗

MYCN Enhances P-gp/MDR1 Gene Expression in the Human Metastatic Neuroblastoma IGR-N-91 ModelSemantic proximity Read ↗

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cellsSemantic proximity Read ↗

Expression of the multidrug resistance-associated protein (MRP) and chemoresistance of human non-small-cell lung cancer cellsSemantic proximity Read ↗

Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression.Semantic proximity Read ↗

Expression of the multidrug resistance, MDR1, gene in neuroblastomas.Semantic proximity Read ↗

ABCC11/MRP8 confers pemetrexed resistance in lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.