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Article

Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.

Molecular endocrinology (Baltimore, Md.) - 1 Oct 1993

Zavacki A M, Harney J W, Brent G A, Larsen P R

Abstract excerpt

The heterogeneity of tissue-specific manifestations of generalized resistance to thyroid hormone (GRTH) could result from differential interactions between the mutant thyroid hormone (T3) receptor-beta (TR beta) on T3 response elements (TREs) in different T3-responsive genes. To explore this hypothesis, the mutant TR beta associated with kindred A, P448H; a TR beta mutant, P448L; and a comparable TR alpha mutant...

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PMID: 8264663
DOI: 10.1210/mend.7.10.8264663

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