Article
Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific.
Molecular endocrinology (Baltimore, Md.) - 1 Oct 1993
Zavacki A M, Harney J W, Brent G A, Larsen P R
Abstract excerpt
The heterogeneity of tissue-specific manifestations of generalized resistance to thyroid hormone (GRTH) could result from differential interactions between the mutant thyroid hormone (T3) receptor-beta (TR beta) on T3 response elements (TREs) in different T3-responsive genes. To explore this hypo...
Topics
- Animals
- Base Sequence
- Cell Line
- Chickens
- Chloramphenicol O-Acetyltransferase
- DNA
- Gene Expression
- Growth Hormone
- Histidine
- Malate Dehydrogenase
- Mice
- Molecular Sequence Data
- Muramidase
- Mutagenesis, Site-Directed
- Mutation
- Proline
- Rats
- Receptors, Thyroid Hormone