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Article

Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone.

Molecular endocrinology (Baltimore, Md.) - 1 Jan 1997

Safer J D, Langlois M F, Cohen R, Monden T, John-Hope D, Madura J, Hollenberg A N, Wondisford F E

Abstract excerpt

Resistance to thyroid hormone (RTH) is due to mutations in the beta-isoform of the thyroid hormone receptor (TR-beta). The mutant TR interferes with the action of normal TR to cause the clinical syndrome. Selective pituitary resistance to thyroid hormone (PRTH) results in inappropriate TSH secretion and peripheral sensitivity to elevated thyroid hormone levels. Association of the PRTH phenotype with in vitro...

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Identifiers

PMID: 8994184
DOI: 10.1210/mend.11.1.9867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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