Article
Isoform variable action among thyroid hormone receptor mutants provides insight into pituitary resistance to thyroid hormone.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1997
Safer J D, Langlois M F, Cohen R, Monden T, John-Hope D, Madura J, Hollenberg A N, Wondisford F E
Abstract excerpt
Resistance to thyroid hormone (RTH) is due to mutations in the beta-isoform of the thyroid hormone receptor (TR-beta). The mutant TR interferes with the action of normal TR to cause the clinical syndrome. Selective pituitary resistance to thyroid hormone (PRTH) results in inappropriate TSH secret...
Topics
- Alleles
- Animals
- Cell Line
- Chlorocebus aethiops
- Dose-Response Relationship, Drug
- Drug Resistance
- Genes, Dominant
- Genes, Reporter
- Humans
- Hypothalamo-Hypophyseal System
- Hypothalamus
- Mutagenesis, Site-Directed
- Pituitary Gland, Anterior
- Receptors, Retinoic Acid