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Article

Suppression of lung cancer cell growth by ribozyme-mediated modification of p53 pre-mRNA.

Cancer gene therapy - 1 Sept 1995

Cai D W, Mukhopadhyay T, Roth J A

Abstract excerpt

An anti-p53 ribozyme (catalytic RNA) designed to cleave the p53 pre-messenger RNA (mRNA) can efficiently reduce the level of endogenous mutant p53 mRNA. Retrovirus-mediated transduction of a hammerhead ribozyme (Rz5a) designed to cleave unspliced p53 RNA at codon 187 near the boundary of intron 5...

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Identifiers

PMID: 8528963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8528963-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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