Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of telomerase activity by a hammerhead ribozyme targeting the RNA component of telomerase in human melanoma cells.

The Journal of investigative dermatology - 1 Feb 2000

Folini M, Colella G, Villa R, Lualdi S, Daidone M G, Zaffaroni N

Abstract excerpt

Reactivation of telomerase, an RNA-dependent DNA polymerase that synthesizes new telomeric repeats at the end of chromosomes, is a very common feature in human cancers. Telomerase is thought to be essential in maintaining the proliferative capacity of tumor cells and, as a consequence, it could represent an attractive target for new anti-cancer therapies. In this study, we generated a hammerhead ribozyme composed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Phenotype
Share to RNA
Share to RNA, Catalytic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Telomerase

Share to Telomere

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 10651984
DOI: 10.1046/j.1523-1747.2000.00870.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of telomerase activity by a hammerhead ribozyme targeting the RNA component of telomerase in human melanoma cells.PMID 10651984Read ↗

Telomerase Activity in Melanoma: Impact on Cancer Cell Proliferation Kinetics, Tumor Progression, and Clinical Therapeutic Strategies—A Scoping ReviewSemantic proximity Read ↗

Telomerase Inhibition in Cancer Therapeutics: Molecular-Based ApproachesSemantic proximity Read ↗

Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairmentSemantic proximity Read ↗

Synthetic Hammerhead Ribozymes as Therapeutic Tools to Control Disease GenesSemantic proximity Read ↗

Mutated telomeres sensitize tumor cells to anticancer drugs independently of telomere shortening and mechanisms of telomere maintenance.Semantic proximity Read ↗

Recent Patents on Anti-Telomerase Cancer TherapySemantic proximity Read ↗

Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells.Semantic proximity Read ↗

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma.Semantic proximity Read ↗

H-ras ribozyme-mediated alteration of the human melanoma phenotype.Semantic proximity Read ↗

Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNASemantic proximity Read ↗

Antitumor activity of systemically delivered ribozymes targeting murine telomerase RNA.Semantic proximity Read ↗

Harnessing Telomerase in Cancer TherapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.