Pharmacogenetics of antidepressants: clinical aspects.

doi:10.1111/j.1600-0447.1997.tb05954.x

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Article

Pharmacogenetics of antidepressants: clinical aspects.

Acta psychiatrica Scandinavica. Supplementum - 1 Jan 1997

Bertilsson L, Dahl M L, Tybring G

Abstract excerpt

Plasma concentrations and response to antidepressants vary considerably between patients treated with similar dosages. Most antidepressants and also antipsychotics are metabolized by the polymorphic debrisoquine/sparteine hydroxylase, i.e., cytochrome P450 (CYP)2D6. About 7% of Caucasians are poo...

Topics

Adult
Aged
Antidepressive Agents
Antidepressive Agents, Tricyclic
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Depression
Dose-Response Relationship, Drug
Drug Interactions
Female
Genetic Variation
Humans
Metabolic Clearance Rate
Pharmacoepidemiology
Polymorphism, Genetic
Psychotropic Drugs
Racial Groups

Source

Open in PubMed

Identifiers

PMID: 9265947
DOI: 10.1111/j.1600-0447.1997.tb05954.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9265947-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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