The evolution of major histocompatibility class I genes in primates.

doi:10.1615/critrevimmunol.v15.i1.10

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Article

The evolution of major histocompatibility class I genes in primates.

Critical reviews in immunology - 1 Jan 1995

Watkins D I

Abstract excerpt

MHC class I genes evolve by recombination, largely within loci, and selection (presumably pathogen-driven) maintains these new alleles in the population. Although chimpanzees and humans share an A locus allelic lineage, the B locus molecules of the chimpanzee were less similar to human B locus molecules. The A and B locus molecules in rhesus and cynomolgus monkeys were even less similar to their human...

Topics

Amino Acid Sequence
Animals
Consensus Sequence
Disease Susceptibility
Evolution, Molecular
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
HLA Antigens
HLA-B Antigens
Humans
Indians, North American
Indians, South American
Infections
Major Histocompatibility Complex
Male
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8519421
DOI: 10.1615/critrevimmunol.v15.i1.10

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