Article
Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes.
Nature - 5 Jul 1990
Watkins D I, Chen Z W, Hughes A L, Evans M G, Tedder T F, Letvin N L
Abstract excerpt
The products of the classical human major histocompatibility complex (MHC) class I genes (HLA-A, -B, -C) are highly polymorphic molecules that bind peptides and present them to T lymphocytes. The non-polymorphic, non-classical MHC class I gene products (HLA-E, -F, -G) are not restricting elements...
Topics
- Amino Acid Sequence
- Animals
- Biological Evolution
- Callitrichinae
- Cloning, Molecular
- DNA
- Genes
- Genetic Variation
- HLA Antigens
- Histocompatibility Antigens Class I
- Humans
- Major Histocompatibility Complex