Development and characterization of hydrogen peroxide-resistant Chinese hamster ovary (CHO) cell variants--II. Relationships between non-protein sulfhydryl levels and the induction/stability of the oxidant-resistant phenotype.

Abstract excerpt

Hydrogen peroxide sensitive and resistant sublines of Chinese hamster ovary (CHO) cells were tested for their non-protein sulfhydryl (NPSH) content in an attempt to establish whether a relationship exists between resistance to growth inhibition elicited by the oxidant and the NPSH pool. Cell vari...

Topics

• Animals
• Buthionine Sulfoximine
• CHO Cells
• Cell Division
• Cricetinae
• Cricetulus
• Drug Resistance
• Hydrogen Peroxide
• Methionine Sulfoximine
• Phenotype
• Sulfhydryl Compounds