CHO.K1 cell mutants sensitive to active oxygen-generating agents. I. Isolation and genetic studies.

doi:10.1016/0027-5107(94)90077-9

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Article

CHO.K1 cell mutants sensitive to active oxygen-generating agents. I. Isolation and genetic studies.

Mutation research - 1 Nov 1994

Hama-Inaba H, Shimazu Y, Takusagawa M, Sato K, Morimyo M

Abstract excerpt

Nine mutants isolated from CHO.K1 cells with increased sensitivity to the lethal effect of plumbagin (PG), a powerful superoxide generator, were classified into five groups, A-E, according to their sensitivity to PG and methyl viologen (MV). Two mutants of group B (Pa13 and Pb4) were sensitive to...

Topics

Animals
Antineoplastic Agents
CHO Cells
Cell Survival
Cricetinae
Genetic Complementation Test
Mutation
Naphthoquinones
Paraquat
Reactive Oxygen Species

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