MDBK cells which survived infection with a mutant of influenza virus A/WSN and subsequently received many passages contained viral M and NS genes in full length in the absence of virus production.

Abstract excerpt

From a variant of MDBK cell line carrying the nucleotide sequences specific to a mutant of influenza virus A/WSN, we obtained cDNA clones representing viral M and NS genes in full length by polymerase chain reaction (PCR). The sequence analysis of five cDNA clones each for the respective genes revealed 4 to 10 base changes with M and 2 to 6 with NS compared with the corresponding genes of the original virus,...

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