Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.

doi:10.1128/JVI.79.3.1918-1923.2005

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Article

Attenuating mutations of the matrix gene of influenza A/WSN/33 virus.

Journal of virology - 1 Feb 2005

Liu Teresa, Ye Zhiping

Abstract excerpt

The matrix protein (M1) of influenza virus plays an essential role in viral replication. Our previous studies have shown that basic amino acids 101RKLKR105 of M1 are involved in RNP binding and nuclear localization. For the present work, the functions of 101RKLKR105 were studied by introducing mutations into the M gene of influenza virus A/WSN/33 by reverse genetic methods. Individual substitution, R101S or...

Topics

Animals
Cell Line
Dogs
Humans
Influenza A virus
Influenza, Human
Lung
Mice
Mice, Inbred BALB C
Mutation
Nucleic Acid Hybridization
Temperature
Viral Matrix Proteins
Virulence
Virus Replication

Source

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Identifiers

PMID: 15650216
DOI: 10.1128/JVI.79.3.1918-1923.2005
PMCID: PMC544140

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