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Article

The multistep nature of cancer.

Trends in genetics : TIG - 1 Apr 1993

Vogelstein B, Kinzler K W

Abstract excerpt

Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete...

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PMID: 8516849
DOI: 10.1016/0168-9525(93)90209-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8516849-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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