Article
Fibronectin splice variants: Understanding their multiple roles in health and disease using engineered mouse models
22 Jun 2011
Abstract excerpt
The extracellular matrix (ECM) is a highly dynamic network of proteins, glycoproteins, and proteoglycans. Numerous diseases result from mutation in genes coding for ECM proteins, but only recently it has been reported that mutations in the fibronectin (FN) gene were associated with a human disorder. FN is one of the main components of the ECM. It generates protein diversity through alternative splicing of a...
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