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The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection

1 Jan 2012

Abstract excerpt

Pathogen persistence in immune-competent hosts represents an immunological paradox. Increasing evidence suggests that some pathogens, such as, Leishmania major (L. major) have evolved strategies and mechanisms that actively suppress host adaptive immunity. If this notion is correct conventional vaccination therapies may be ineffective in enhancing host immunity, unless natural processes that suppress host...

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PMID: 22230608
DOI: 10.1186/1423-0127-19-5

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