Article
LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction.
Cell - 18 Jun 1993
Kim B, Little J W
Abstract excerpt
During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far sl...
Topics
- Bacterial Proteins
- Binding Sites
- DNA-Binding Proteins
- Enzyme Activation
- Enzymes
- Escherichia coli
- Gene Expression Regulation, Bacterial
- Mutation
- Rec A Recombinases
- Repressor Proteins
- Serine Endopeptidases
- Substrate Specificity
- Viral Proteins
- Viral Regulatory and Accessory Proteins