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Article

Reaction of LexA repressor with diisopropyl fluorophosphate. A test of the serine protease model.

The Journal of biological chemistry - 5 Aug 1990

Roland K L, Little J W

Abstract excerpt

The LexA repressor of Escherichia coli modulates the expression of the SOS regulon. In the presence of DNA damaging agents in vivo, the 202-amino acid LexA repressor is inactivated by specific RecA-mediated cleavage of the Ala-84/Gly-85 peptide bond. In vitro. LexA cleavage requires activated RecA at neutral pH, and proceeds spontaneously at high pH in an intramolecular reaction termed autodigestion. A model has...

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PMID: 2198279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reaction of LexA repressor with diisopropyl fluorophosphate. A test of the serine protease model.PMID 2198279Read ↗

Mutant LexA proteins with an increased rate of in vivo cleavage.Semantic proximity Read ↗

In vitro analysis of mutant LexA proteins with an increased rate of specific cleavage.Semantic proximity Read ↗

Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis.Semantic proximity Read ↗

A brief consideration of the SOS inducing signal.Semantic proximity Read ↗

Regulation of the SOS response in Bacillus subtilis: evidence for a LexA repressor homolog.Semantic proximity Read ↗

Alteration of lysine 178 in the hinge region of the Escherichia coli ada protein interferes with activation of ada, but not alkA, transcription.Semantic proximity Read ↗

Altered nucleotide cofactor-dependent properties of the mutant [S240K]RecA protein.Semantic proximity Read ↗

LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction.Semantic proximity Read ↗

Disruption of an ATP-dependent isomerization of the recA protein by mutation of histidine 163.Semantic proximity Read ↗

SOS response induction by beta-lactams and bacterial defense against antibiotic lethality.Semantic proximity Read ↗

Intradomain LexA rotation is a prerequisite for DNA binding specificity.Semantic proximity Read ↗

An obligatory pH-mediated isomerization on the [Asn-160]recA protein-promoted DNA strand exchange reaction pathway.Semantic proximity Read ↗

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