Article
Parental allele specific methylation of the human insulin-like growth factor II gene and Beckwith-Wiedemann syndrome.
Journal of medical genetics - 1 May 1993
Schneid H, Seurin D, Vazquez M P, Gourmelen M, Cabrol S, Le Bouc Y
Abstract excerpt
In an attempt to elucidate the role of methylation in parental imprinting at the IGF-II gene locus, for which imprinting has already been described in the mouse, we undertook an allele specific methylation study of the human IGF-II gene (mapped to 11p15.5) in a control population and in patients...
Topics
- Adult
- Alleles
- Beckwith-Wiedemann Syndrome
- Blotting, Northern
- Blotting, Southern
- Calcitonin
- Child
- Chromosomes, Human, Pair 11
- DNA
- Fathers
- Female
- Gene Expression Regulation
- Gene Frequency
- Humans
- Immunoblotting
- Insulin
- Insulin-Like Growth Factor II
- Leukocytes