Article
An insertion-deletion event in murine immunoglobulin kappa gene resembles mutations at heavy-chain disease loci.
Somatic cell and molecular genetics - 1 Mar 1993
Chou C L, Morrison S L
Abstract excerpt
The analysis of spontaneous somatic mutants gives insights into the regulation of gene expression. Human heavy-chain disease (HCD) is a monoclonal lymphoproliferative disorder characterized by the presence of truncated immunoglobulin (Ig) heavy chains without associated light chains. To better un...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Cloning, Molecular
- DNA
- Heavy Chain Disease
- Humans
- Immunoglobulin kappa-Chains
- Mice
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Restriction Mapping
- Tumor Cells, Cultured