Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus.

doi:10.1002/eji.1830250715

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Article

Rearrangement of upstream DH and VH genes to a rearranged immunoglobulin variable region gene inserted into the DQ52-JH region of the immunoglobulin heavy chain locus.

European journal of immunology - 1 Jul 1995

Taki S, Schwenk F, Rajewsky K

Abstract excerpt

We investigated gene rearrangements in the mutant IgH locus of a mouse strain generated by insertion of a rearranged heavy chain variable region gene (VT15) into the DQ52-JH region through gene targeting. In more than half of the B cells of heterozygous mutant mice, the mutant IgH locus was silenced by the rearrangement of an endogenous DH or DH and VH gene to the inserted VT15 gene. In these cases, a functional...

Topics

Alleles
Animals
Antibodies, Monoclonal
B-Lymphocytes
Base Sequence
Consensus Sequence
DNA Primers
Female
Gene Expression
Gene Rearrangement, B-Lymphocyte, Heavy Chain
Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Immunoglobulin Heavy Chains

Immunoglobulin Variable Region

Male

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Source

Open in PubMed

Identifiers

PMID: 7621865
DOI: 10.1002/eji.1830250715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7621865-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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