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Article

Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription

15 Jun 1993

Abstract excerpt

The expression of the hematopoietic transcription factors GATA-1, GATA-2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas...

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PMID: 8507862
DOI: 10.1182/blood.v81.12.3234.3234

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