Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Bronchial Epithelial Cell–derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation

30 Aug 2017

Abstract excerpt

Abstract Activated bronchial epithelial cells (BEC) release various alarmins, including thymic stromal lymphopoietin (TSLP), that drive type 2 inflammation. We hypothesize that BEC-derived factors promote in situ eosinophil differentiation and maturation, a process that is driven by an IL-5–rich microenvironment in asthmatic airways. To assess the eosinophilopoietic potential of epithelial-derived factors,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to IL-33, ST2, and ILC Pathways
Share to Pediatric health and respiratory diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28853918
DOI: 10.1165/rcmb.2016-0262oc

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Bronchial Epithelial Cell–derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil DifferentiationPMID 28853918Read ↗

Eosinophil specialization is regulated by exposure to the esophageal epithelial microenvironmentSemantic proximity Read ↗

Sputum IL-25, IL-33 and TSLP, IL-23 and IL-36 in airway obstructive diseases. Reduced levels of IL-36 in eosinophilic phenotype.Semantic proximity Read ↗

Comparison of IL-33 and IL-5 Family Mediated Activation of Human EosinophilsSemantic proximity Read ↗

Distinct roles for thymic stromal lymphopoietin (TSLP) and IL-33 in experimental eosinophilic esophagitisSemantic proximity Read ↗

High transcriptional activity and clinical correlations in eosinophils of patients with late-onset asthmaSemantic proximity Read ↗

Transcription Factors in Eosinophil Development and As Therapeutic TargetsSemantic proximity Read ↗

Transcription factor and cytokine regulation of eosinophil lineage commitmentSemantic proximity Read ↗

IL-1 Family Members IL-18 and IL-33 Upregulate the Inflammatory Potential of Differentiated Human Th1 and Th2 CulturesSemantic proximity Read ↗

Targeting eosinophil biology in asthma therapy.Semantic proximity Read ↗

Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice.Semantic proximity Read ↗

Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production.Semantic proximity Read ↗

Transcriptional Profiling of Mouse Eosinophils Identifies Distinct Gene Signatures Following Cellular ActivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.