Article
Gene expression of the GATA-3 transcription factor is increased in atopic asthma.
The Journal of allergy and clinical immunology - 1 Feb 1999
Nakamura Y, Ghaffar O, Olivenstein R, Taha R A, Soussi-Gounni A, Zhang D H, Ray A, Hamid Q
Abstract excerpt
BACKGROUND: High expression of IL-5 by T cells in the airways of asthmatic individuals is believed to play a fundamental role in the eosinophilia associated with this disease. Recently, the transcription factor GATA-3 was shown to be critical for IL-5 gene expression in TH2 cells in vitro. OBJECT...
Topics
- Adult
- Asthma
- Bronchi
- DNA-Binding Proteins
- Female
- GATA3 Transcription Factor
- Gene Expression Regulation
- Humans
- Hypersensitivity, Immediate
- Immunochemistry
- In Situ Hybridization
- Interleukin-5
- Male
- Middle Aged
- Phenotype
- RNA, Messenger
- Trachea
- Trans-Activators