Article
Identification of a substrate recognition site on Ubc9.
The Journal of biological chemistry - 14 Jun 2002
Lin Donghai, Tatham Michael H, Yu Bin, Kim Suhkmann, Hay Ronald T, Chen Yuan
Abstract excerpt
Human Ubc9 is homologous to ubiquitin-conjugating enzymes. However, instead of conjugating ubiquitin, it conjugates a ubiquitin homologue, small ubiquitin-like modifier 1 (SUMO-1), also known as UBL1, GMP1, SMTP3, PIC1, and sentrin. The SUMO-1 conjugation pathway is very similar to that of ubiquitin with regard to the primary sequences of the ubiquitin-activating enzymes (E1), the three-dimensional structures of...
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