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Article

Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole.

The Journal of cell biology - 1 Jan 1995

Chang A, Fink G R

Abstract excerpt

We have characterized a class of mutations in PMA1, (encoding plasma membrane ATPase) that is ideal for the analysis of membrane targeting in Saccharomyces cerevisiae. This class of pma1 mutants undergoes growth arrest at the restrictive temperature because newly synthesized ATPase fails to be targeted to the cell surface. Instead, mutant ATPase is delivered to the vacuole, where it is degraded. Delivery to the...

Topics

Amino Acid Sequence
Cell Membrane
Genes, Fungal
Genotype
Kinetics
Molecular Sequence Data
Mutagenesis
Plasmids
Proton-Translocating ATPases
Saccharomyces cerevisiae
Sequence Homology, Amino Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Temperature

Vacuoles

Source

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Identifiers

PMID: 7822420
DOI: 10.1083/jcb.128.1.39
PMCID: PMC2120329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7822420-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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