Article

Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression

2025-02-07

Abstract excerpt

<title>Abstract</title> <p>Purpose Segmental gain of chromosome 17q is the most common genetic aberration in high-risk neuroblastoma, but its role in disease progression is poorly understood. This study aims to address the contribution of 17q gain to neuroblastoma malignancy. Patients and methods: We analyzed the genetic and transcriptional landscape of 417 neuroblastoma patients across various risk groups and...

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Literature Corpus work: 36da978e-6863-57a6-a351-95e5d3e37636
DOI: 10.21203/rs.3.rs-5961130/v1

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