Article
Relation of phenotype evolution of HIV-1 to envelope V2 configuration.
Science (New York, N.Y.) - 4 Jun 1993
Groenink M, Fouchier R A, Broersen S, Baker C H, Koot M, van't Wout A B, Huisman H G, Miedema F, Tersmette M, Schuitemaker H
Abstract excerpt
Biological variability of human immunodeficiency virus type-1 (HIV-1) is involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Syncytium-inducing (SI) HIV-1 variants emerge in 50 percent of infected individuals during infection, preceding accelerated CD4+ T cell loss and rapi...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Consensus Sequence
- Genetic Variation
- Giant Cells
- HIV Envelope Protein gp120
- HIV Seropositivity
- HIV-1
- Humans
- Male
- Molecular Sequence Data
- Phenotype
- Protein Conformation
- Recombination, Genetic