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Article

Relation of phenotype evolution of HIV-1 to envelope V2 configuration.

Science (New York, N.Y.) - 4 Jun 1993

Groenink M, Fouchier R A, Broersen S, Baker C H, Koot M, van't Wout A B, Huisman H G, Miedema F, Tersmette M, Schuitemaker H

Abstract excerpt

Biological variability of human immunodeficiency virus type-1 (HIV-1) is involved in the pathogenesis of acquired immunodeficiency syndrome (AIDS). Syncytium-inducing (SI) HIV-1 variants emerge in 50 percent of infected individuals during infection, preceding accelerated CD4+ T cell loss and rapid progression to AIDS. The V1 to V2 and V3 region of the viral envelope glycoprotein gp120 contained the major...

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Identifiers

PMID: 8502996
DOI: 10.1126/science.8502996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Relation of phenotype evolution of HIV-1 to envelope V2 configuration.PMID 8502996Read ↗

Temporal relationship between elongation of the HIV type 1 glycoprotein 120 V2 domain and the conversion toward a syncytium-inducing phenotype.Semantic proximity Read ↗

Maintenance of syncytium-inducing phenotype of HIV type 1 is associated with positively charged residues in the HIV type 1 gp120 V2 domain without fixed positions, elongation, or relocated N-linked glycosylation sites.Semantic proximity Read ↗

In vivo sequence variability of human immunodeficiency virus type 1 envelope gp120: association of V2 extension with slow disease progression.Semantic proximity Read ↗

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Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.Semantic proximity Read ↗

Role of CCR2 genotype in the clinical course of syncytium-inducing (SI) or non-SI human immunodeficiency virus type 1 infection and in the time to conversion to SI virus variants.Semantic proximity Read ↗

Simple determination of human immunodeficiency virus type 1 syncytium-inducing V3 genotype by PCR.Semantic proximity Read ↗

Molecular determinants of human immunodeficiency virus type I phenotype variability.Semantic proximity Read ↗

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Envelope V3 amino acid sequence predicts HIV-1 phenotype (co-receptor usage and tropism for macrophages).Semantic proximity Read ↗

Genetic diversity of the highly variable V1 region interferes with Human Immunodeficiency Virus type 1 envelope functionality.Semantic proximity Read ↗

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