Article
Footprinting the sites of interaction of antibiotics with catalytic group I intron RNA.
Science (New York, N.Y.) - 4 Jun 1993
von Ahsen U, Noller H F
Abstract excerpt
Aminoglycoside inhibitors of translation have been shown previously to inhibit in vitro self-splicing by group I introns. Chemical probing of the phage T4-derived sunY intron shows that neomycin, streptomycin, and related antibiotics protected the N-7 position of G96, a universally conserved guanine in the binding site for the guanosine cofactor in the splicing reaction. The antibiotics also disrupted structural...
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