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Article

Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element.

1 Jun 1993

Abstract excerpt

B-cell-specific expression of the immunoglobulin kappa light-chain (Ig kappa) gene is in part accomplished by negative regulatory influences. Here we describe a new negatively acting element (termed kappa NE) immediately upstream of the NF-kappa B-binding site in the Ig kappa intronic enhancer. The 27-bp kappa NE sequence is conserved in the corresponding positions in the rabbit and human Ig kappa genes, and the...

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Identifiers

PMID: 8497276
DOI: 10.1128/mcb.13.6.3698

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Source receipt: pubmed, retrieved 7 Sept 2026.

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