Article
Isolation of STD1, a high-copy-number suppressor of a dominant negative mutation in the yeast TATA-binding protein.
Molecular and cellular biology - 1 Jun 1993
Ganster R W, Shen W, Schmidt M C
Abstract excerpt
The TATA-binding protein (TBP) is an essential component of the transcriptional machinery of all three nuclear RNA polymerase enzymes. Comparison of the amino acid sequence of TBPs from a number of species reveals a highly conserved 180-residue C-terminal domain. In contrast, the N terminus is variable in both size and amino acid sequence. Overexpression of a TBP protein with a deletion of the nonconserved N...
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