Requirements for the generation of a Lyt-2+ T-cell proliferative response to a syngeneic tumor in the absence of L3T4+ T-cells.

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Article

Requirements for the generation of a Lyt-2+ T-cell proliferative response to a syngeneic tumor in the absence of L3T4+ T-cells.

Cancer research - 1 Oct 1990

Kern D E, Klarnet J P, Cheever M A, Greenberg P D

Abstract excerpt

Tumors may contain immunogenic antigens that are only recognizable in the context of class I, and not of class II, MHC molecules. Therefore, methods were developed to analyze the capacity of Lyt-2+ T-cells to respond to a syngeneic tumor in the absence of a contribution by L3T4+ T-cells. Conditions were defined in which purified Lyt-2+ T-cell populations, as well as L3T4+ T-cell populations, isolated from immune...

Topics

Animals
Antigen-Presenting Cells
Female
Friend murine leukemia virus
Immunity, Cellular
Interleukin-1
Interleukin-2
Isoantibodies
Leukemia, Experimental
Lymphocyte Activation
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Major Histocompatibility Complex

Mice

Mice, Inbred BALB C

Mice, Inbred CBA

Phenotype

Retroviridae Proteins, Oncogenic

T-Lymphocytes, Helper-Inducer

Source

Open in PubMed

Identifiers

PMID: 2144789

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2144789-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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