Human macrophages induced in vitro by macrophage colony-stimulating factor are deficient in IL-12 production.

doi:10.1002/(SICI)1521-4141(199808)28:08<2498::AID-IMMU2498>3.0.CO;2-Q

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Article

Human macrophages induced in vitro by macrophage colony-stimulating factor are deficient in IL-12 production.

European journal of immunology - 1 Aug 1998

Smith W, Feldmann M, Londei M

Abstract excerpt

IL-12 is important for Th1 differentiation. Myeloid-derived antigen-presenting cells (APC) such as monocytes, macrophages (Mphi) and dendritic cells (DC) are believed to be major sources of IL-12 in vivo. We have compared IL-12 production of fresh monocytes with Mphi differentiated in vitro using...

Topics

Cell Differentiation
Dendritic Cells
Humans
In Vitro Techniques
Interleukin-10
Interleukin-12
Listeria monocytogenes
Macrophage Colony-Stimulating Factor
Macrophages
Monocytes
Neutralization Tests
Phenotype

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