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Article

Pathogen-induced Th1 phenotype development in CD4+ alpha beta-TCR transgenic T cells is macrophage dependent.

International immunology - 1 Apr 1993

Hsieh C S, Macatonia S E, O'Garra A, Murphy K M

Abstract excerpt

We used an ovalbumin (OVA)-specific alpha beta-TCR transgenic mouse system to examine the cellular basis of CD4+ T helper (Th) phenotype development in vitro. Heat-killed Listeria monocytogenes (HKLM) strongly promotes the in vitro development of a Th1 phenotype in OVA-specific transgenic T cells...

Topics

Animals
CD4 Antigens
Cytokines
Female
In Vitro Techniques
Interferon-gamma
Interleukin-10
Interleukin-4
Listeria monocytogenes
Macrophages
Mice
Mice, Inbred BALB C
Mice, Inbred CBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Ovalbumin

Phenotype

Receptors, Antigen, T-Cell, alpha-beta

T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 8494824
DOI: 10.1093/intimm/5.4.371

Genes

APC
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8494824-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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