Article
Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.
Science (New York, N.Y.) - 23 Apr 1993
Hsieh C S, Macatonia S E, Tripp C S, Wolf S F, O'Garra A, Murphy K M
Abstract excerpt
Development of the appropriate CD4+ T helper (TH) subset during an immune response is important for disease resolution. With the use of naïve, ovalbumin-specific alpha beta T cell receptor transgenic T cell, it was found that heat-killed Listeria monocytogenes induced TH1 development in vitro through macrophage production of interleukin-12 (IL-12). Moreover, inhibition of macrophage production of IL-12 may...
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