Article
Lipopeptides of Borrelia burgdorferi outer surface proteins induce Th1 phenotype development in alphabeta T-cell receptor transgenic mice.
Infection and immunity - 1 Oct 1997
Infante-Duarte C, Kamradt T
Abstract excerpt
Induction of the appropriate T helper cell (Th) subset is crucial for the resolution of infectious diseases and the prevention of immunopathology. Some pathogens preferentially induce Th1 or Th2 responses. How microorganisms influence Th phenotype development is unknown. We asked if Borrelia burg...
Topics
- Animals
- Bacterial Outer Membrane Proteins
- Borrelia burgdorferi Group
- Cells, Cultured
- Enterobacteriaceae
- Interleukin-12
- Lipoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Oligopeptides
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- Species Specificity
- T-Lymphocytes
- Th1 Cells