Article
Oncogenes in cellular immortalisation and differentiation (review).
Anticancer research - 1 Jan 2000
Gonos E S, Spandidos D A
Abstract excerpt
Oncogenes have been shown to be able to overcome the limited proliferative capacity of normal mammalian cells in culture enforcing them to an immortalised phenotype, which in turn may act as a primary step in tumourigenesis. The oncogenes which display such immortalisation activity have the commo...
Topics
- Animals
- Cell Differentiation
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Genes, myc
- Genes, ras
- Humans
- Oncogenes
- Phenotype