Oncogenes in cellular immortalisation and differentiation (review).

Abstract excerpt

Oncogenes have been shown to be able to overcome the limited proliferative capacity of normal mammalian cells in culture enforcing them to an immortalised phenotype, which in turn may act as a primary step in tumourigenesis. The oncogenes which display such immortalisation activity have the common feature of nuclear localisation, while the oncogenes which are capable of transforming cells are mainly cytoplasmic....

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