Article
Carcinogenesis in mouse and human cells: parallels and paradoxes.
Carcinogenesis - 1 Mar 2000
Balmain A, Harris C C
Abstract excerpt
It has been known since the last century that genetic changes are important in carcinogenesis [Boveri,T. (1914) Zur Frage der Erstehung Maligner Tumoren. Gustav Fischer, Jena]. Observations of tumor cells growing in tissue culture led to the prediction, even before the true nature of the genetic material was known, that alterations at the chromosomal level were critically involved in the process of neoplastic...
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