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Article

Reversal of left-right asymmetry: a situs inversus mutation.

Science (New York, N.Y.) - 30 Apr 1993

Yokoyama T, Copeland N G, Jenkins N A, Montgomery C A, Elder F F, Overbeek P A

Abstract excerpt

A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left-right polarity (situs inversus) in 100 percent of the homozygous transgenic mice tested. Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci. During early embryonic development, the direction of postimplantation turning, one of the...

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Source

Identifiers

PMID: 8480178
DOI: 10.1126/science.8480178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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