Article
TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice.
Cell - 23 Apr 1993
Luetteke N C, Qiu T H, Peiffer R L, Oliver P, Smithies O, Lee D C
Abstract excerpt
To explore the physiological roles of transforming growth factor alpha (TGF alpha), we disrupted the mouse gene by homologous recombination in embryonic stem cells. Homozygous mutant mice were viable and fertile, but displayed pronounced waviness of the whiskers and fur, accompanied by abnormal curvature, disorientation, and misalignment of the hair follicles. Homozygous and, to a lesser extent, heterozygous mice...
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