Article
Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1996
Berkowitz E A, Seroogy K B, Schroeder J A, Russell W E, Evans E P, Riedel R F, Phillips H K, Harrison C A, Lee D C, Luetteke N C
Abstract excerpt
The spontaneous mouse waved 1 (wa1) mutation is allelic with the transforming growth factor alpha (TGF-alpha) gene and produces phenotypes similar to those of TGF-alpha knockout mice. Here, we show that TGF-alpha mRNA and protein levels are measurable in wa1 tissues but reduced 5- to 30-fold relative to wild type. Because the wa1-coding sequence is identical to that of the normal mRNA, wa1 is not a null mutation....
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