Article
Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.
Cell - 23 Apr 1993
Mann G B, Fowler K J, Gabriel A, Nice E C, Williams R L, Dunn A R
Abstract excerpt
Mice homozygous for a disrupted transforming growth factor alpha (TGF alpha) gene are healthy and fertile, although some older mice show evidence of corneal inflammation. In contrast with TGF alpha +/- and +/+ animals, TGF alpha -/- mice have a pronounced waviness of the coat. Histological examin...
Topics
- Animals
- Base Sequence
- Chimera
- Epidermal Growth Factor
- Epithelial Cells
- Eye Abnormalities
- Female
- Gene Deletion
- Hair
- Keratitis
- Male
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Oligodeoxyribonucleotides
- Skin