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Article

Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2002

Flügel-Koch Cassandra, Ohlmann Andreas, Piatigorsky Joram, Tamm Ernst R

Abstract excerpt

Previous experiments showed that transgenic mice expressing a secreted self-activating transforming growth factor (TGF) -beta1 did not show a phenotype in the lens and cornea until postnatal day 21, when anterior subcapsular cataracts, sporadic thickening of the corneal stroma, and thinning of the corneal epithelium were noted (Srinivasan et al., 1998). To examine the effects of higher concentrations of TGF-beta1...

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Identifiers

PMID: 12242711
DOI: 10.1002/dvdy.10144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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