Lens expression of TGF alpha in transgenic mice produces two distinct eye pathologies in the absence of tumors.

Article

Lens expression of TGF alpha in transgenic mice produces two distinct eye pathologies in the absence of tumors.

Oncogene - 1 Jul 1994

Decsi A, Peiffer R L, Qiu T, Lee D C, Friday J T, Bautch V L

Abstract excerpt

Transgenic mice carrying the rat TGF alpha minigene linked to the alpha A crystallin promoter were generated to investigate the effects of expression of this growth factor in the lens of the eye. All transgenic mice exhibited eye abnormalities in the absence of overt tumors, and two distinct and...

Topics

Animals
Animals, Newborn
Eye Abnormalities
Eye Neoplasms
Female
In Situ Hybridization
Lens, Crystalline
Male
Mice
Mice, Transgenic
Pedigree
Phenotype
Transforming Growth Factor alpha

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