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Article

Lens expression of TGF alpha in transgenic mice produces two distinct eye pathologies in the absence of tumors.

Oncogene - 1 Jul 1994

Decsi A, Peiffer R L, Qiu T, Lee D C, Friday J T, Bautch V L

Abstract excerpt

Transgenic mice carrying the rat TGF alpha minigene linked to the alpha A crystallin promoter were generated to investigate the effects of expression of this growth factor in the lens of the eye. All transgenic mice exhibited eye abnormalities in the absence of overt tumors, and two distinct and heritable phenotypes were observed. Five lineages produced 'squinting' transgenic mice characterized by microphthalmic...

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PMID: 8208543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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