Article
T cell line passage can select for pre-existing neutralization-sensitive variants from the quasispecies of primary human immunodeficiency virus type-1 isolates.
Virology - 1 Mar 2007
Quakkelaar Esther D, Beaumont Tim, van Nuenen Ad C, van Alphen Floris P J, Boeser-Nunnink Brigitte D M, van 't Wout Angélique B, Schuitemaker Hanneke
Abstract excerpt
Primary human immunodeficiency type 1 viruses (HIV-1) resist antibody neutralization but become sensitive after passage through T cell lines. We and others previously reported an increased neutralization sensitivity of HIV-1 after prolonged culture on primary peripheral blood mononuclear cells (PBMC). Hence we hypothesized that adaptation to growth in T cell lines is in fact selection of a pre-existing...
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